Issues in Calibrations and Accuracy in Method Validation

Duration 60 Mins
Level Intermediate
Webinar ID IQW20H0832

  • Comparison by using standards – the types of standards
  • Traceability and documentation
  • Calibration curves – checks for linearity, when non-linearity happens
  • Spikes, surrogates, and standard addition
  • Monitoring calibrations – slope and intercept

Overview of the webinar

One of the most important concepts and criteria of Good Laboratory Practices is accuracy, how well does a methodology stand in terms of quantifying when compared to an expected value? There are various approaches in calibration and in the use of standards for comparisons. This webinar will cover the validation of calibrations and the strengths, weaknesses, and appropriateness of the different types of standards.

Who should attend?

  • Lab Chemists
  • Lab Managers
  • Lab Technicians
  • Lab Analysts
  • Industries into Compliance Methodology (Biotech, Pharma)
  • Companies into Environmental Compliance or EPA

Why should you attend?

Without accuracy, a result is not acceptable. There are many issues that affect accuracy and there are many approaches to deal with them. The importance of response, matrix effects, the selectivity of identification, and other issues will be covered.

  • How accuracy is determined
  • What are the various types of standards and what are their strengths and weaknesses
  • The importance of traceability
  • Calibration curves – what are the important criteria? Linearity versus nonlinearity, slope, intercept and what they mean
  • Matrix effects and how to deal with them
  • Using calibration data to monitor performance

Faculty - Mr. John Fetzer

Dr. John C. Fetzer, PhD offers over 20 years of expertise in Analytical Chemistry, focusing on Polycyclic Aromatic Hydrocarbons, Petroleum and its Products, Chromatography, and UV and Fluorescence Spectroscopy. He offers Analytical Chemistry Consulting Services and Scientific Career Development Consulting services to companies, organizations, and individuals. Dr. Fetzer has over a decade of experience as a supervisor, team leader, trainer, and coach. He has published over 100 peer-reviewed scientific publications, 2 books, and 8 book chapters. 
Dr. Fetzer is an American Chemical Society tour speaker, who has participated in over twenty invited lectures at conferences, universities, and government laboratories.

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